Targeting cyclooxygenase-2 in human neoplasia
نویسندگان
چکیده
منابع مشابه
Cyclooxygenase-1 and -2: Molecular Targets for Cervical Neoplasia
Cyclooxygenase (COX) is a key enzyme responsible for inflammation, converting arachidonic acid to prostaglandin and thromboxane. COX has at least two isoforms, COX-1 and COX-2. While COX-1 is constitutively expressed in most tissues for maintaining physiologic homeostasis, COX-2 is induced by inflammatory stimuli including cytokines and growth factors. Many studies have shown that COX-2 contrib...
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On the basis of epidemiological observations that nonsteroidal antiinflammatory drugs reduce the risk of esophageal carcinoma, we studied the expression of cyclooxygenase-2 (COX-2) in esophageal squamous cell carcinomas (SCCs; n = 172) and in esophageal adenocarcinomas (ADCs; n = 27). Using immunohistochemistry, we observed COX-2 expression in 91% of the SCCs and in 78% of the ADCs. Western blo...
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1David H. Koch Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX; 2Department of Biological and Environmental Sciences, Division of Biochemistry, The University of Helsinki, Helsinki, Finland; 3Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX; 4Department of Molecular Cell Function, Graduate School in Medical and Pharmaceut...
متن کاملLentivirus-mediated shRNA interference targeting cyclooxygenase-2 inhibits growth of human non-small cell lung cancer.
PURPOSE Cyclooxygenase-2 (COX-2), one isoform of cyclooxygenase proinflammatory enzymes, plays an important role in tumor development and progression. Researches of human cancers have revealed high expression levels of COX-2 in a variety of cancers including lung cancer. The mechanism of COX-2 in the pathogenesis of non-small cell lung cancer (NSCLC) cells is not well understood. METHODS We c...
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Anti-angiogenic therapies were approved for different cancers. However, significant primary and secondary resistance hampers efficacy in several tumor types including breast cancer. Thus, we need to develop clinically applicable strategies to enhance efficacy of anti-angiogenic drugs.We report that anti-angiogenic therapies can induce upregulation of cyclooxygenase-2 (Cox-2) and of its product ...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2003
ISSN: 1535-6108
DOI: 10.1016/s1535-6108(03)00310-6